General Drug Trends in the United States

The Most Significant Drug Threats Identified by HIDTA Directors for Calendar Year 2023

Information prepared by the National Emerging Trends Initiative (NETI)

Greatest Drug Threat
Fentanyl and methamphetamine were listed most frequently as the greatest drug threats throughout the United States in 2023.

Second Greatest Drug Threat

Third Greatest Drug Threat  


Fourth Greatest Drug Threat









Drugs of Abuse
Drug Enforcement Administration, December 2022


2020 National Drug Threat Assessment
Drug Enforcement Administration, March 2021 (most current version)


Mexico: Organized Crime and Drug Trafficking Organizations
Congressional Research Service, Updated June 2022

National Drug Control Strategy
The White House, Office of the President
Office of National Drug Control Policy (ONDCP), April 2022
Additional Strategies: